Background Inadequate knowledge among health care providers (HCPs) and parents of affected children limits the understanding and utility of secondary genetic findings (SFs) in under-represented populations in genomics research. SFs arise from deep DNA sequencing done for research or diagnostic purposes and may burden patients and their families despite their potential health importance. This study aims to evaluate the perspective of both groups regarding SFs and their choices in the return of results from genetic testing in the context of orofacial (...) clefts.Methods Using an online survey, we evaluated the experiences of 252 HCPs and 197 parents across participating cleft clinics in Ghana and Nigeria toward the return of SFs across several domains.Results Only 1.6% of the HCPs felt they had an expert understanding of when and how to incorporate genomic medicine into practice, while 50.0% agreed that all SFs should be returned to patients. About 95.4% of parents were willing to receive all the information from genetic testing (including SFs), while the majority cited physicians as their primary information source (64%).Conclusions Overall, parents and providers were aware that genetic testing could help in the clinical management of diseases. However, they cited a lack of knowledge about genomic medicine, uncertain clinical utility, and lack of available learning resources as barriers. The knowledge gained from this study will assist with developing guidelines and policies to guide providers on the return of SFs in sub-Saharan Africa and across the continent. (shrink)

The debate on the influence of markets on virtues has focused on two opposite hypotheses: the doux commerce thesis and the self-destruction thesis. Whereas the doux commerce hypothesis assumes that capitalism polishes human manners, the self-destruction hypothesis holds that capitalism erodes the moral foundation of society. This paper will develop a more balanced position by using the virtue ethics developed by Aristotle, which distinguishes several virtues. The research will focus on the question for which virtues the doux commerce or self-destruction (...) thesis is likely to hold. An extensive literature survey shows that market competition tends to stimulate diligence, crowd out temperance, generosity, and sociability, and stimulate envy. The effect on other virtues – i.e. courage, high-spiritedness, justice, and prudence – is ambiguous. (shrink)

Neuroethics, as a domain of inquiry, was made necessary by this interdisciplinary march of technology that has been much documented and the resulting synergism, which resulted in the development of neuroimaging, deep brain stimulation, and advanced neuropharmaceutics. Closing the loop from discovery of basic mechanisms of illness to knowledge of structure and function en route to restorative therapeutics is a long way from earlier efforts to use electrical stimulation to address human maladies. The most challenging aspect about neuroethics is that (...) the technology used by neuroscientists needs to be understood in order to offer responsible neuroethical critique. The technocentricity of neuroscience makes it especially vulnerable to broader market forces and the sway of political economy, all of which might be exacerbated by the recent fiscal melt down and recent trends in healthcare reform. These challenges are illustrated by investigational work exploring the use of deep brain stimulation in the minimally conscious state. (shrink)

Book reviewed in this article:F.H. Bradley, Collected Works Volumes 1–5.

Calvin’s view on the legitimacy of interest has had a great impact on the economic development of Western society. Although Calvin took a fundamentally positive attitude to interest, he also proposed several restrictions on the charging of interest. In this article, we investigate the relevance of these restrictions to the current credit crisis. We find that each of them provides a relevant interpretation of what went wrong in the buildup of the credit crisis and gives directions to improve policies of (...) banks and governments as well. (shrink)

In his philosophical works Seneca often refers to the views of his predecessors, and sometimes is the sole or the earliest authority for what he says about them, which makes it important for the student of earlier thought to know whether what he says is likely to be true. This I believe can be roughly assessed–and this paper is an attempt to do it–by considering how reliable he is in places where he can be checked: that is, in places where (...) he refers to earlier writings which survive. I shall be principally concerned with his Naturales Quaestiones and with early meteorology: with considering how accurately Seneca reports Aristotle's Meteorologica, and trying to estimate therefrom the reliability of his statements about pre-Socratic meteorology; but I believe that my conclusions should also be applicable to what Seneca says on later thinkers and other subjects. (shrink)

This article indicates some ways in which the fantasy of the brain in the vat has been used in thought experiments to discuss important philosophical problems. The first has to do with scepticism about the external world. The second has to do with Hilary Putnam’s arguments for the indeterminacy of reference and his rejection of metaphysical realism. The third issue to which the brain in the vat is relevant has to do with the difference between broad and narrow content of (...) beliefs and Putnam’s challenging assertion that reference is not ‘in the head’. Though there are brief suggestions for dealing with these problems and saving metaphysical realism, the main purpose is to indicate the relevance of the fantasy of the brain in the vat to discussion of these issues. (shrink)

I come to praise contemporary French philosophy not to bury it. My aim is not to hail the appearance in France of a native brand of analytic philosophy—in itself an important event in the last decade—but to describe the indirect and selective importation of certain Anglo-Saxon concepts by French philosophers whose practice is far from analytic; and also to describe the resultant misunderstanding. In this paper I shall analyse the use of pragmatic concepts—and of the concept ‘pragmatics’—in the recent work (...) by Deleuze and Guattari, Mille Plateaux, and I shall try to show that these concepts are the object of a creative misunderstanding, of a misprision. (shrink)